In this murder mystery special, The Griffins as well as all the other major characters become trapped in a mansion while they are killed off one by one.

When Brian learns that Rush Limbaugh (guest-voicing as himself) is going to be at the Quahog Mall for a book-signing, he decides to go down there and give him a piece of his left-wing mind. But when Rush unexpectedly comes to Brian's rescue, Brian has a political change of heart

After Peter catches Lois' dad, Carter, having an affair, he is strong-armed into keeping a secret. But when Peter accidentally spills the beans, Lois' mom demands a divorce, and Peter is in charge of Carter's return to bachelorhood

Peter and Joe team up to execute a series of painful and humiliating Halloween pranks on unsuspecting family, friends and neighbors. While Brian shows Stewie the ropes of trick-or-treating, Meg sets out to attend her first high school Halloween party with high hopes for the evening.

When Peter receives tickets to a boxing match as a birthday gift, he volunteers Lois to compete. To everyone's surprise, Lois dominates in the ring, and Peter decides to become her fight promoter. Her frustration with Peter turns into motivation in the ring as the housewife turns champion.

Feeling discouraged with the progress of his writing career, Brian decides to throw in the towel until Stewie become his manager and one of his books hits the bestseller list. But when the fame goes to his head, Brian gets a wake-up call from Bill Maher. Meanwhile, Lois decides that she and Peter need separate beds, a decision that leaves Peter looking for a new cuddle buddy.

Stewie's favorite thing after his teddy bear, Rupert, is Christmas. So when he hears that Santa is making an appearance at the mall, he begs Brian to take him so that he can tell Santa in person what he wants for Christmas. Brian begrudgingly takes Stewie to the mall, only to get the brush-off from Santa. As a result, Stewie and Brian travel to the North Pole to find Santa and teach him a lesson in holiday cheer

Peter needs a new kidney after his energy-drink addiction causes renal failure. Meanwhile, Chris is chosen to introduce President Obama at school after winning an essay contest. Trouble is, Meg wrote the essay.

Lois becomes friends with Joyce Kinney, the new local news anchor, and Joyce convinces Lois to let her do a story on her as the model American housewife. The television story makes Lois look terrible, and Joyce is unapologetic, leaving Lois no choice but to right a wrong

Brian and Peter are required to attend a 12-step program to deal with their drinking problems; Death (Adam Carolla) gives Peter a glimpse of what life would be like without alcohol.

On the search to find a new hobby, Chris meets a puppeteer named Franz, an old friend of Herbert's. Despite Herbert's warnings, Chris and Franz remain friends until Franz's checkered past

When Bonnie goes out of town, Meg offers to check in on Joe, but she soon becomes a little too involved and starts freaking everyone out - especially Joe. Meanwhile, Stewie thinks he's losing his edge as the toughest baby on the block, so he hooks himself up to a machine that is supposed to make him more evil than ever before.

Chris and Meg think their parents have it easy, but Peter and Lois beg to differ, so in order to teach them a lesson, they all trade roles. Chris goes to work at the brewery while Meg runs the house. While things start off well, it's not long until the stress of running a household and being the sole breadwinner break down Chris and Meg

When the local dry cleaner loses Peter's favorite white shirt, he goes ballistic. Meanwhile, Brian tries to score on a date with a new friend, Denise (guest voice Stroup), but ends up striking out. Instead of calling it quits on love, he decides to enlist Quagmire's help, but things get nasty when they start to compete for the affections of each other's old flames, Cheryl Tiegs (guest-voicing as herself) and Jillian (guest voice Barrymore)

Mayor West and Carol, Lois' sister, tie the knot in (s9e15) . They move in with the Griffins, and become part of the happy family. To accommodate the new couple, Stewie has to give up his room, and move to Chris' room, a move that does not make either Stewie or Chris happy. But the move has a positive side, in that Peter and Mayor West become the best of friends.

Reading up on art and literature, Stewie and Brian get heavily involved. They concentrate on the lives of the painters of old, especially the famous ones like Michael Angelo and Leonardo da Vinci. On reading the life story of Leonardo da Vinci, they find he was killed by a guy called Bertram. In an effort to turn back the clock in (s9e16) , Stewie and Brian go back into the past, to stop this killing.

When Bonnie and Lois take a trip to Paris, Bonnie crosses the line while in the City of Love. Meanwhile, Peter homes chools Chris and Meg using some unorthodox teaching methods.

After a third power blackout, the family (albeit reluctantly) tells the story of "Star Wars: Return of the Jedi".